Principales Cliniques et Hôpitaux Privés pour la Transplantation Hépatique en Suisse

En Suisse, les principales cliniques privées offrent des soins avancés en matière de transplantation hépatique, notamment pour les cas graves. Ces établissements rassemblent des spécialistes de premier plan qui combinent expertise médicale et technologies innovantes pour assurer des procédures de transplantation réussies et des suivis post-opératoires personnalisés.

Liver transplantation (LT) has revolutionized outcomes for cirrhotic patients. Current liver allocation policies dictate patients with highest short-term mortality receive the highest priority, thus, several patients become increasingly ill on the waitlist. Given cirrhosis is a progressive disease, it can be complicated by the occurrence of acute-on-chronic liver failure (ACLF), a syndrome defined by an acute deterioration of liver function associated with extrahepatic organ failures requiring intensive care support and a high short-term mortality. Successfully bridging to transplant includes accurate prognostication and prioritization of ACLF patients awaiting LT, optimizing intensive care support pre-LT, and tailoring immunosuppressive and anti-infective therapies post-LT. Furthermore, predicting futility (too sick to undergo LT) in ACLF is challenging. In this review, we summarize the role of LT in ACLF specifically highlighting (a) current prognostic scores in ACLF, (b) critical care management of the ACLF patient awaiting LT, (c) donor issues to consider in transplant in ACLF, and (d) exploring of recent post-LT outcomes in ACLF and potential opportunities to improve outcomes including current care gaps and unmet research needs. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.